Distinct regions of the Phytophthora essential effector Avh238 determine its function in cell death activation and plant immunity suppression.
Identifieur interne : 000A26 ( Main/Exploration ); précédent : 000A25; suivant : 000A27Distinct regions of the Phytophthora essential effector Avh238 determine its function in cell death activation and plant immunity suppression.
Auteurs : Bo Yang [République populaire de Chine] ; Qunqing Wang [République populaire de Chine] ; Maofeng Jing [République populaire de Chine] ; Baodian Guo [République populaire de Chine] ; Jiawei Wu [République populaire de Chine] ; Haonan Wang [République populaire de Chine] ; Yang Wang [République populaire de Chine] ; Long Lin [République populaire de Chine] ; Yan Wang [République populaire de Chine] ; Wenwu Ye [République populaire de Chine] ; Suomeng Dong [République populaire de Chine] ; Yuanchao Wang [République populaire de Chine]Source :
- The New phytologist [ 1469-8137 ] ; 2017.
Descripteurs français
- KwdFr :
- Immunité des plantes (MeSH), Maladies des plantes (immunologie), Maladies des plantes (microbiologie), Mort cellulaire (MeSH), Noyau de la cellule (métabolisme), Phytophthora (isolement et purification), Phytophthora (métabolisme), Plantes (immunologie), Plantes (microbiologie), Polymorphisme génétique (MeSH), Protéines (composition chimique), Protéines (métabolisme), Séquence d'acides aminés (MeSH), Transport des protéines (MeSH).
- MESH :
- composition chimique : Protéines.
- immunologie : Maladies des plantes, Plantes.
- isolement et purification : Phytophthora.
- microbiologie : Maladies des plantes, Plantes.
- métabolisme : Noyau de la cellule, Phytophthora, Protéines.
- Immunité des plantes, Mort cellulaire, Polymorphisme génétique, Séquence d'acides aminés, Transport des protéines.
English descriptors
- KwdEn :
- Amino Acid Sequence (MeSH), Cell Death (MeSH), Cell Nucleus (metabolism), Phytophthora (isolation & purification), Phytophthora (metabolism), Plant Diseases (immunology), Plant Diseases (microbiology), Plant Immunity (MeSH), Plants (immunology), Plants (microbiology), Polymorphism, Genetic (MeSH), Protein Transport (MeSH), Proteins (chemistry), Proteins (metabolism).
- MESH :
- chemical , chemistry : Proteins.
- immunology : Plant Diseases, Plants.
- isolation & purification : Phytophthora.
- metabolism : Cell Nucleus, Phytophthora, Proteins.
- microbiology : Plant Diseases, Plants.
- Amino Acid Sequence, Cell Death, Plant Immunity, Polymorphism, Genetic, Protein Transport.
Abstract
Phytophthora pathogens secrete effectors to manipulate host innate immunity, thus facilitating infection. Among the RXLR effectors highly induced during Phytophthora sojae infection, Avh238 not only contributes to pathogen virulence but also triggers plant cell death. However, the detailed molecular basis of Avh238 functions remains largely unknown. We mapped the regions responsible for Avh238 functions in pathogen virulence and plant cell death induction using a strategy that combines investigation of natural variation and large-scale mutagenesis assays. The correlation between cellular localization and Avh238 functions was also evaluated. We found that the 79th residue (histidine or leucine) of Avh238 determined its cell death-inducing activity, and that the 53 amino acids in its C-terminal region are responsible for promoting Phytophthora infection. Transient expression of Avh238 in Nicotiana benthamiana revealed that nuclear localization is essential for triggering cell death, while Avh238-mediated suppression of INF1-triggered cell death requires cytoplasmic localization. Our results demonstrate that a representative example of an essential Phytophthora RXLR effector can evolve to escape recognition by the host by mutating one nucleotide site, and can also retain plant immunosuppressive activity to enhance pathogen virulence in planta.
DOI: 10.1111/nph.14430
PubMed: 28134441
Affiliations:
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210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author><author><name sortKey="Dong, Suomeng" sort="Dong, Suomeng" uniqKey="Dong S" first="Suomeng" last="Dong">Suomeng Dong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yuanchao" sort="Wang, Yuanchao" uniqKey="Wang Y" first="Yuanchao" last="Wang">Yuanchao Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28134441</idno><idno type="pmid">28134441</idno><idno type="doi">10.1111/nph.14430</idno><idno type="wicri:Area/Main/Corpus">000A53</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000A53</idno><idno type="wicri:Area/Main/Curation">000A53</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000A53</idno><idno type="wicri:Area/Main/Exploration">000A53</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Distinct regions of the Phytophthora essential effector Avh238 determine its function in cell death activation and plant immunity suppression.</title><author><name sortKey="Yang, Bo" sort="Yang, Bo" uniqKey="Yang B" first="Bo" last="Yang">Bo Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Qunqing" sort="Wang, Qunqing" uniqKey="Wang Q" first="Qunqing" last="Wang">Qunqing Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Shandong Agricultural University, Taian, 271018, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Shandong Agricultural University, Taian, 271018</wicri:regionArea><wicri:noRegion>271018</wicri:noRegion></affiliation></author><author><name sortKey="Jing, Maofeng" sort="Jing, Maofeng" uniqKey="Jing M" first="Maofeng" last="Jing">Maofeng Jing</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author><author><name sortKey="Guo, Baodian" sort="Guo, Baodian" uniqKey="Guo B" first="Baodian" last="Guo">Baodian Guo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Jiawei" sort="Wu, Jiawei" uniqKey="Wu J" first="Jiawei" last="Wu">Jiawei Wu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Haonan" sort="Wang, Haonan" uniqKey="Wang H" first="Haonan" last="Wang">Haonan Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yang" sort="Wang, Yang" uniqKey="Wang Y" first="Yang" last="Wang">Yang Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Long" sort="Lin, Long" uniqKey="Lin L" first="Long" last="Lin">Long Lin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yan" sort="Wang, Yan" uniqKey="Wang Y" first="Yan" last="Wang">Yan Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author><author><name sortKey="Ye, Wenwu" sort="Ye, Wenwu" uniqKey="Ye W" first="Wenwu" last="Ye">Wenwu Ye</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author><author><name sortKey="Dong, Suomeng" sort="Dong, Suomeng" uniqKey="Dong S" first="Suomeng" last="Dong">Suomeng Dong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yuanchao" sort="Wang, Yuanchao" uniqKey="Wang Y" first="Yuanchao" last="Wang">Yuanchao Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095</wicri:regionArea><wicri:noRegion>210095</wicri:noRegion></affiliation></author></analytic><series><title level="j">The New phytologist</title><idno type="eISSN">1469-8137</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence (MeSH)</term><term>Cell Death (MeSH)</term><term>Cell Nucleus (metabolism)</term><term>Phytophthora (isolation & purification)</term><term>Phytophthora (metabolism)</term><term>Plant Diseases (immunology)</term><term>Plant Diseases (microbiology)</term><term>Plant Immunity (MeSH)</term><term>Plants (immunology)</term><term>Plants (microbiology)</term><term>Polymorphism, Genetic (MeSH)</term><term>Protein Transport (MeSH)</term><term>Proteins (chemistry)</term><term>Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Immunité des plantes (MeSH)</term><term>Maladies des plantes (immunologie)</term><term>Maladies des plantes (microbiologie)</term><term>Mort cellulaire (MeSH)</term><term>Noyau de la cellule (métabolisme)</term><term>Phytophthora (isolement et purification)</term><term>Phytophthora (métabolisme)</term><term>Plantes (immunologie)</term><term>Plantes (microbiologie)</term><term>Polymorphisme génétique (MeSH)</term><term>Protéines (composition chimique)</term><term>Protéines (métabolisme)</term><term>Séquence d'acides aminés (MeSH)</term><term>Transport des protéines (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Proteins</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Protéines</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Maladies des plantes</term><term>Plantes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Plant Diseases</term><term>Plants</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Phytophthora</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Phytophthora</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Nucleus</term><term>Phytophthora</term><term>Proteins</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Maladies des plantes</term><term>Plantes</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Plant Diseases</term><term>Plants</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Noyau de la cellule</term><term>Phytophthora</term><term>Protéines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Cell Death</term><term>Plant Immunity</term><term>Polymorphism, Genetic</term><term>Protein Transport</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Immunité des plantes</term><term>Mort cellulaire</term><term>Polymorphisme génétique</term><term>Séquence d'acides aminés</term><term>Transport des protéines</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Phytophthora pathogens secrete effectors to manipulate host innate immunity, thus facilitating infection. Among the RXLR effectors highly induced during Phytophthora sojae infection, Avh238 not only contributes to pathogen virulence but also triggers plant cell death. However, the detailed molecular basis of Avh238 functions remains largely unknown. We mapped the regions responsible for Avh238 functions in pathogen virulence and plant cell death induction using a strategy that combines investigation of natural variation and large-scale mutagenesis assays. The correlation between cellular localization and Avh238 functions was also evaluated. We found that the 79<sup>th</sup> residue (histidine or leucine) of Avh238 determined its cell death-inducing activity, and that the 53 amino acids in its C-terminal region are responsible for promoting Phytophthora infection. Transient expression of Avh238 in Nicotiana benthamiana revealed that nuclear localization is essential for triggering cell death, while Avh238-mediated suppression of INF1-triggered cell death requires cytoplasmic localization. Our results demonstrate that a representative example of an essential Phytophthora RXLR effector can evolve to escape recognition by the host by mutating one nucleotide site, and can also retain plant immunosuppressive activity to enhance pathogen virulence in planta.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28134441</PMID><DateCompleted><Year>2018</Year><Month>02</Month><Day>16</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1469-8137</ISSN><JournalIssue CitedMedium="Internet"><Volume>214</Volume><Issue>1</Issue><PubDate><Year>2017</Year><Month>Apr</Month></PubDate></JournalIssue><Title>The New phytologist</Title><ISOAbbreviation>New Phytol</ISOAbbreviation></Journal><ArticleTitle>Distinct regions of the Phytophthora essential effector Avh238 determine its function in cell death activation and plant immunity suppression.</ArticleTitle><Pagination><MedlinePgn>361-375</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/nph.14430</ELocationID><Abstract><AbstractText>Phytophthora pathogens secrete effectors to manipulate host innate immunity, thus facilitating infection. Among the RXLR effectors highly induced during Phytophthora sojae infection, Avh238 not only contributes to pathogen virulence but also triggers plant cell death. However, the detailed molecular basis of Avh238 functions remains largely unknown. We mapped the regions responsible for Avh238 functions in pathogen virulence and plant cell death induction using a strategy that combines investigation of natural variation and large-scale mutagenesis assays. The correlation between cellular localization and Avh238 functions was also evaluated. We found that the 79<sup>th</sup> residue (histidine or leucine) of Avh238 determined its cell death-inducing activity, and that the 53 amino acids in its C-terminal region are responsible for promoting Phytophthora infection. Transient expression of Avh238 in Nicotiana benthamiana revealed that nuclear localization is essential for triggering cell death, while Avh238-mediated suppression of INF1-triggered cell death requires cytoplasmic localization. Our results demonstrate that a representative example of an essential Phytophthora RXLR effector can evolve to escape recognition by the host by mutating one nucleotide site, and can also retain plant immunosuppressive activity to enhance pathogen virulence in planta.</AbstractText><CopyrightInformation>© 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Bo</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Qunqing</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Plant Pathology, Shandong Agricultural University, Taian, 271018, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jing</LastName><ForeName>Maofeng</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Baodian</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Jiawei</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Haonan</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Long</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ye</LastName><ForeName>Wenwu</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dong</LastName><ForeName>Suomeng</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yuanchao</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education), Nanjing, 210095, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>01</Month><Day>30</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>New Phytol</MedlineTA><NlmUniqueID>9882884</NlmUniqueID><ISSNLinking>0028-646X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011506">Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>New Phytol. 2017 Apr;214(1):8-10</RefSource><PMID Version="1">28239893</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016923" MajorTopicYN="N">Cell Death</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002467" MajorTopicYN="N">Cell Nucleus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010838" MajorTopicYN="N">Phytophthora</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010935" MajorTopicYN="N">Plant Diseases</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D057865" MajorTopicYN="Y">Plant Immunity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010944" MajorTopicYN="N">Plants</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011110" MajorTopicYN="N">Polymorphism, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D021381" MajorTopicYN="N">Protein Transport</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011506" MajorTopicYN="N">Proteins</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Phytophthora sojae
</Keyword><Keyword MajorTopicYN="N">RXLR effector</Keyword><Keyword MajorTopicYN="N">cell death</Keyword><Keyword MajorTopicYN="N">immunosuppression</Keyword><Keyword MajorTopicYN="N">localization</Keyword><Keyword MajorTopicYN="N">virulence</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>09</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>12</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>1</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>2</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>1</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28134441</ArticleId><ArticleId IdType="doi">10.1111/nph.14430</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Yang, Bo" sort="Yang, Bo" uniqKey="Yang B" first="Bo" last="Yang">Bo Yang</name></noRegion><name sortKey="Dong, Suomeng" sort="Dong, Suomeng" uniqKey="Dong S" first="Suomeng" last="Dong">Suomeng Dong</name><name sortKey="Dong, Suomeng" sort="Dong, Suomeng" uniqKey="Dong S" first="Suomeng" last="Dong">Suomeng Dong</name><name sortKey="Guo, Baodian" sort="Guo, Baodian" uniqKey="Guo B" first="Baodian" last="Guo">Baodian Guo</name><name sortKey="Guo, Baodian" sort="Guo, Baodian" uniqKey="Guo B" first="Baodian" last="Guo">Baodian Guo</name><name sortKey="Jing, Maofeng" sort="Jing, Maofeng" uniqKey="Jing M" first="Maofeng" last="Jing">Maofeng Jing</name><name sortKey="Jing, Maofeng" sort="Jing, Maofeng" uniqKey="Jing M" first="Maofeng" last="Jing">Maofeng Jing</name><name sortKey="Lin, Long" sort="Lin, Long" uniqKey="Lin L" first="Long" last="Lin">Long Lin</name><name sortKey="Lin, Long" sort="Lin, Long" uniqKey="Lin L" first="Long" last="Lin">Long Lin</name><name sortKey="Wang, Haonan" sort="Wang, Haonan" uniqKey="Wang H" first="Haonan" last="Wang">Haonan Wang</name><name sortKey="Wang, Haonan" sort="Wang, Haonan" uniqKey="Wang H" first="Haonan" last="Wang">Haonan Wang</name><name sortKey="Wang, Qunqing" sort="Wang, Qunqing" uniqKey="Wang Q" first="Qunqing" last="Wang">Qunqing Wang</name><name sortKey="Wang, Qunqing" sort="Wang, Qunqing" uniqKey="Wang Q" first="Qunqing" last="Wang">Qunqing Wang</name><name sortKey="Wang, Qunqing" sort="Wang, Qunqing" uniqKey="Wang Q" first="Qunqing" last="Wang">Qunqing Wang</name><name sortKey="Wang, Yan" sort="Wang, Yan" uniqKey="Wang Y" first="Yan" last="Wang">Yan Wang</name><name sortKey="Wang, Yan" sort="Wang, Yan" uniqKey="Wang Y" first="Yan" last="Wang">Yan Wang</name><name sortKey="Wang, Yang" sort="Wang, Yang" uniqKey="Wang Y" first="Yang" last="Wang">Yang Wang</name><name sortKey="Wang, Yang" sort="Wang, Yang" uniqKey="Wang Y" first="Yang" last="Wang">Yang Wang</name><name sortKey="Wang, Yuanchao" sort="Wang, Yuanchao" uniqKey="Wang Y" first="Yuanchao" last="Wang">Yuanchao Wang</name><name sortKey="Wang, Yuanchao" sort="Wang, Yuanchao" uniqKey="Wang Y" first="Yuanchao" last="Wang">Yuanchao Wang</name><name sortKey="Wu, Jiawei" sort="Wu, Jiawei" uniqKey="Wu J" first="Jiawei" last="Wu">Jiawei Wu</name><name sortKey="Wu, Jiawei" sort="Wu, Jiawei" uniqKey="Wu J" first="Jiawei" last="Wu">Jiawei Wu</name><name sortKey="Yang, Bo" sort="Yang, Bo" uniqKey="Yang B" first="Bo" last="Yang">Bo Yang</name><name sortKey="Ye, Wenwu" sort="Ye, Wenwu" uniqKey="Ye W" first="Wenwu" last="Ye">Wenwu Ye</name><name sortKey="Ye, Wenwu" sort="Ye, Wenwu" uniqKey="Ye W" first="Wenwu" last="Ye">Wenwu Ye</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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